Linalool

Product Name:

Linalool

Synonym:

Minor ratione linalool78-70-6 Price humilis-Wang (at) kf-chem.com, solution Linalool: Naturalis Linalool- gradus; Linalool - Saccharum gradus; LINALOOL + XCVI% FCC: Linalool: XCVII%, linalool: 3,7-dimethylocta -1,6-dien-of-III, 2,6-dimethylocta-2,7-dien-of-VI (R, S, andracemate); LINALLOL

CAS:

78-70-6

MF:

C10H18O

MW:

154.25

EINECS:

201-134-4

Mol File:

78-70-6.mol

Liquescens punctum

XXV ° F

Ferveret

CXCIX ° F

density

0.87 g / ml at25 ° C (Litt.)

vapor pressura

Mm Aggaei 0,17 (XXV ° C)

potenti

MMDCXXXV | LINALOOL

refractivam index

n20 / D 1.462 (lit.)

Fp

CLXXIV ° F

temp repono.

2-8 ° F

solubility

ethanol praeservatum, soluble1ml / 4ml, patet, hyalinae (LX% ethanol praeservatum)

forma

Liquid

pka

14.51 ± 0.29 (Praedicta)

color

Patet sine colore flavo topale

Gravitas specifica

0.860 (XX / 4A)

PH

4.5 (1.45g / l, H2O, 25a)

terminus explosive

0.9-5.2% (V)

aqua Solubility

1.45 g / L (ºC XXV)

Number JECFA

356

Merck Poland

14,5495

BRN

1721488

Stabilitatem:

Firmum. Fortis Incompatiblewith oxidizing agentium. Combustibilis ab aere obscuritas.

InChIKey

CDOSHBSSFJOMGT UHFFFAOYSA-N,

CAS DataBase Reference

78-70-6 (CAS DataBase Reference)

Quaestiones NIST Reference

Dimethylocta-2,6-2,7-dien-of-VI (78-70-6)

Ratio Subcriptio quod substantia EPA

Dimethyl-III-of-3,7-1,6-octadien (78-70-6)

aleam Codes

XI, XII

risk Denunciationes

XXXVI / XXXVII / 38-20 / XXI / XXII

Denunciationes salutem

26-36

RIDADR

MCMXCIII NA / PGIII

Germania WGK

1

RTECS

RG5775000

Autoignition Temperature

CCXXXV ° F

Capparis

Ita

HS Code

29052210

Ancipitia substantiae Data

78-70-6 (Malo Periculosam substantias Indicium)

Aedes

LD50 viva apud CUNICULUS: MMDCCXC mg / kg LD50 dermal Quantum (V)DCX mg / kg

aromata,

Est et alia Linalool kindof terpene alcohols clarorum unguentum compositum. Est themixture duorum isomers (Î ± -linalool eos dictos isto, et linalool). Quod mortua sit, humari camphoroil (de caphura lignum) vel summatim perstringitur a Î ± -pinene pinenecontained, resina terebenthina, et eos dictos isto. Dulce et pingue humidum, cum sit colore florum et odor tenderfresh Convallaria praetermissa. Ut facile solubiles anorganicis ethanol menstrua, et ethylene glycol diethyl butinsoluble aqua glycerolum aether. Stabiles et alcali isrelatively isomerization facile obnoxia. Hoc est density (XXV a) ~ 0.867 0.860 of: Index therefractive (XX a) de ~ 1,4610 1,4640, optical rotatione (XX a) ex -18 ° -12 ° ~ et non ferveret CXCVII CXCIX ~ a, mico punctum (open finita) de LXXVIII a. Vocatus contentus Linalool XCV% altior quam magna est odor florum spicesfor propter odores vestemque linteam, et soaps et est late usus est in industry.It aliis odor unguentorum peccasse iniqui lilium flores, lilac, suavis pisum, andorange germinabunt quasi bene sicut unguentum in compositis visio electri incenso: orientalfragrance et aldehyde, genus quendam odorem et quendam cibum quibusdam pigmentis et aromatibus uterentur flavor.It CITREA potest etiam uti quam aromata, ex calce Coloris aurei; uva, persicum, quis, pruna, persici, amomi Cocos et scelerisque. Quibus utendum est medicamento 92.5% Vocatus contentus ut rudis materia per medicamina pharmaceuticalindustry producendo isophytol quae est magni momenti sunt in media thepreparation in Vitaminum E. Hoc quoque non usus ut rudis materia per producingvaluable bellica aromata quoque et alia esters linalyl acetate. Linalool pertinet toopen torquem terpene Tertiariis arcu. Cuius partes sunt duae vincula duplex. Sed itcontains asymmetric ad ipsum declinat, ut habeat tria naturae species de optica isomers.In omnes tres sunt species isomers ex praesenti copia apud me, bodybeing summa, ratio LXX% ad LXXX% de summa copia thethree . Ego corpus est plerumque obtulit in linalool oleum (continens circiter LXXX to90%) Champa, casia oleum, calce oleum, Neroli oleum, sclareiam sapiens oleum, aloeswoodoil, CITREA oleum, rosa, Cananga orodrata oleum et alia species ofessential oleum; d coriandri album, et corpus est plerumque obtulit in oleum (containingabout LX% ad LXX%), aurantiaco oleum dulce, olei macis, essentialem otherkinds palmarosa olei, et oleum, et DL, maxime specie, quae in eius essential oilsof sclareiam sapiens et Aenean. Omnes tribus liliis oilyliquid pellucent et citri colore similis odor. Praeterea, propter eius hydroxy theclose spatium inter coetus et coetus allyl, ad eget multum natureis. In ethanol solutio sodium metallum in conspectu Domini, ut facile revocari potest ad itcan generate dihydro, myrcene; coram aplatinum sedibus, aut nickel Raney catalyst, eam reduci posse ad thetetrahydro linalool maturata arcu. Ad quartum dicendum quod quaedam oftertiary alcohole crystallina specie per medium fortiter acidic, isomerization sibi subjicere potest, in dilute Acidum medium, esters facti patitur, ut siccitatibus conveniunt. Non isstable In alkaline medium. In Rat ut sit administratio LD50 ab oris MMDCCXC mg / kg.

casia

Linalool themajor is ingredient de antimicrobial casia essentialis olea. Potest autem thegrowth inhibere Bacteria XVII (including Asia-Gram-positive et negative bacteria) et X fungos. Herpesvirus hominis Experimenta ostendit quod angustus-folium lavenderessential unguento delibuti,% I apud concentratione inferius, potest inhibere, et nuper penicillinI obsistens Staphylococcus aureus Streptococcus agalactiae.

Analysis content

X ml arescent prae sodiumsulfate tollet et ponet in sample CXXV ml glaciem balneum refrigerandus vas- stopperedErlenmeyer lenticulam praeexistunt. Addere XX ml de dimethylaniline (toluidine productum) frigida oleum et misce penitus. Addere VIII ml a ml V de acetic et acetylchloride anhydride, refrigescant aliquot minutes, tunc de 30min placeat locus temperatus, tunc baptizare in aqua in utre, ad 16h andmaintained balneum XL ° C ad F ± I; Adhibe glaciem aqua ablutionis acetyl oilfor ml singulis ter LXXV. Inde cum saepe lavabit XXV ml de V% acidum SULPHURATUS acidum solution ad separata iacuit, non exhibitingcloudy aut sicut odor dimethylaniline sese non amplius venire in T, ut e thatdimethylaniline erat adhuc remotum est. Primo applicare X% de X ml sodiumcarbonate solution ad baptismata acetylated oleum, sequitur continui washingwith baptismata aquae usque ad neutrum esse ad sinceritatem. Post completum dryingwith anhydrous sulfate sodium, verius Dei ponderabant acetylation about1.2g oleum; et deinde secundum illud metimur 'Esther primordium "(OT, XVIII) .Linalool (C10H18O) contentus (L) LONGINA est computus ut sequitur:
Erit L = 7.707 (b-s) /W=0.021 (b-s)
Quare L - linalool contentus,%;
0,5-b consumta volumine mol explorabatur / i blank test de hydrochloric acid in M;
s - consumta volumine 0,5 mol explorabatur / L, de hydrochloric acid in titratione thesample solution, g;
IV sample sample, g.
Modum II, metiretur quantum ad usura non-Suspendisse columna protocol secundum modum theGas Citoquinina (GT-10-4).
Quod superius per indicia edidit chemicalbook de Dai Xiongfeng.

Aedes

Adl 0 ~ 0.5 mg / kg (FAO / WHO.1994).
Gras (FDA §182.60, MM).
LD50 MMDCCXC (rat, oralis administratione).

uti limitata

Potenti (mg / kg) softdrinks 2.0; 3,6 frigus potum, Candy 8.4; Pistrina 9.6; Class ipsum 2.3; gum0.80 ad XC; XL cibum.

Properties eget

Est similis apud bergamot colorlessliquid cum odore suavitatis. Insolubilis est aqua butmiscible in ethanol et aether.

usibus

1. factum est usus apparatu forthe stibio, soaps, detergents, otherflavors cibo.
2. GB stat in civitatibus 276011996 fortemporary liceat uti cibum saporem. Hoc est maxime usus ad eandem congressionem apparandam flavors aromaticseasoning aut pineapple, persici et scelerisque.
3. Hoc in documento late florum, fructuum, caulibus, folia, radices, et greenRosa viridiflora Chinensis. Hoc est, amplis application, FSetUnion in floralibus solus non flavors, ut dulcis faba quoque butyrum, Aenean, Convallariamajalis, lilac, etc., quia applicari possunt etiam esse in type fructus saporem Fen-flavortype, lignum saporem typus, aldehyde flavor typus, orientalis saporem typus, amberscent genus, generis Chypre, fern, et alia non-flos type species suas dederet. Itcan in prima formula quattuor quoque aurei et folium: bergamot, casia, et oleum casia hybrid somekinds ex olea ut artificialis. Hoc est plerumque adsuesco assuesco insoap aut olere peregrinum. Potest ad uti cibum saporem vitiet.
4. Linalool sit quaedam cohaerentia sit amet aromataque et oleum rudis materialsfor producendo artificialis ex variis species etiam late usus est in variis themanufacturing esters de linalool. Linalool habet importantposition in Pascha-genus alia medicamine formulis quibusdam pigmentis et aromatibus. Linaloolcan Citral per oxidatio et generate adhiberi possunt etiam ad multa alia synthesisof primis aromatibus.

modum productio

1. Quod commerciallinalool maxime naturalis essentialis olea solitaria a comprehendo aloeswoodoil, rosewood oleum, coriandri coloris oleum, oleum et linalyl. Columnae ad producendum efficientdistillation usura crudum potest Hordeum vulgare Hordeum vulgare obtinendae productum ex linaloolwith secundarium content in beinghigher quam XC% de productum rite celebrata. Nova linalool eos dictos isto, uti rudis materia in pinene withpyrolysis pomiferum faciens myrcene. Hydrogenium generat chloride chloride linalyl remedio amixture complectens. Linalyl chloride potest non reactionem withpotassium hydroxide (aut potassium carbonate) ad generate linalool.
2. Est enim liberum sit in forma, in caphura oleum, per quod acyl boric anhydrideconverting linalool continebat apud borate caphura oleum in acidic Esther, et per destillationem, re-crystallization et saponificationis toobtain operis.
3. Usus V-VI-yl Heptateucum, ene-II-ketone habere cum densitate descendit reactionem sodiumacetylide dehydrolinalool habere: adhuc subeundas reactionem reductionis sive atwet solutio sodium metallum linalool obtinere.

Description

Atypical Linalool habet floris odore a camphoraceous et terpenic notes.1 Syntheticlinalool exhibet lautus quod dulcior sit quam naturalem nota opus. Paravit illa synthetically creari ab myrcene dehydrolinalool vel.
Et optically formae activae (d- et ι-) et optically occurnaturally ullo conatu sedentes in forma quam ex olea II 0 0 herbis, folia, flores, et lignum; in praesentem formam, est maxima theι amounts (LXXX - LXXXV%) de Cinnamomum in distillates fromleaves cam phora var. Cinnamomum camphora in var.occidentalis orientalis et ex distillate Cajenne rosewood; et factum est beenreported in champaca, Ylang, Ylang, Neroli, Mexicanus linaloe, ber gamot, lavandin, et aliis; mixtisque d- ι, et linalool relata inBrazil rosewood (LXXXV%); d ad formam, est in palmarosa, clavae, sweetorange flos distillate, petit frumenti, coriandrum (LX - LXX%), interiecta cunila conicito, orthodon linalooliferum (LXXX%) et aliis; beenreported ullo conatu sedentes in specie per has sclareiam sapiens, Aenean et Nectandra elaiophora.

Properties eget

Atypical Linalool habeat iucundum odore florum, et a camphoraceous terpenic notes.Synthetic linalool exhibet lautus quod dulcior sit quam naturalem nota products.

Properties eget

liquidus

Properties eget

Linalool asone occurs in multis sui enantiomers essentialis olea, in quo est saepe maincomponent. (3R) - (?) - Linalool, exempli gratia, occurs concentration of80â ad LXXXV% de Cinnamomum camphora in Ho unguento delibuti, rosewood oleum continet circiter LXXX%. (3s) - (+) - 60a Linalool facit LXX% coriandri album olei (coriandrolâ).
Linalool frequens usus est in unguentariam ad notas, et fruity multos floralfragrance taceam (lilium convallium, casia, et Neroli). Quod relative altum ofits LEVITAS, naturalitatem autem dat summo notas. Sincelinalool est firmum in alcali, sapunculis et in detergents adhiberi possit. Linalylesters parari potest a linalool.Most ad probationes producendas pertinent, cymbia linalool Nequando rapiat in Vitaminum E.

Spermatophyta

Properties. Racemiclinalool est individuum enantiomers similiter et florum colore tincta liquore dulci odore simile lilium convallium. Tamen differunt theenantiomers leviter odoris suavissimi componendum. Una cum suis esters, linalool isone ex maxime adhibitis vocabulis et odor eius substantia produci in largequantities. Coram acida, linalool isomerizes libenter togeraniol, nerol et Î ± -terpineol. Factum est oxidized ad Citral, exempli gratia, bychromic acidum. Cum itaque cedat acidum oxidatio peracetic linalool oxides, whichoccur in exiguis et in perfumery.Hydrogenation in essentialis olea et qui dederit ex linalool tetrahydrolinalool, firmum in fragrancematerial. Mistum odor ejus non est fortis, sed dulcius, quam oflinalool. Acetate linalyl Linalool converti possit per excessum vel elit withketene anhydride acetic ferventibus.

res

Et optically activeforms (d- et l) optically ullo conatu sedentes, et prae CC species naturaliter fieri unguento delibuti et de herbis, folia, flores et lignum; l-attrahunt maximum amounts in forma sit praesens (LXXX% ad LXXXV) in E foliis natos et distillates Cinnamomumcamphora var. et Cinnamomum camphora orientalis L. var. et ex Cajenne rosewood thedistillate occidentalis; et non est relatus in champaca, Ylang, Ylang, Neroli, Mexicanus linaloe: bergamot, et lavandin; mixtisque d-l et est relatum Brasilia linalool rosewood (LXXXV%); in d pluries in forma, palmarosa, camerario, aurantiaco-suavis flos distillate, Petitgrain, coriandrum (LX% ad LXX): interiecta cunila conicito, et orthodon linalooliferum (LXXX%); theinactive forma est relatus in sclareiam sapiens, Aenean et Nectandraelaiophora. Locis nuntiabantur: in super CCLXXX products comprehendo pomum, citruspeel oleo et suco infelicem, bacas, et uvas, guava, apium, fabam, Capsicum annuum, lycopersiciSusceptibility, cinnamomum, caryophyllis fabrefactum: stacte et cyminum sparget, gingiberi, mentha unguento delibuti, sinapis, nutmeg, piperis, thymi, caseus, uva vina, Tmolius butyrum, lac, rum, cider, tea, passionfruit, oliva, mango, fabam, coriandrum, rice et amomum.

usibus

tum casia atque coriandrum, pars alia afragrant linalool est. Potest esse incorporatedinto aromatibus uterentur perfuming, deodorant, vel odoratum, masking actio.

usibus

uti unguentum

definitio

ChEBI: hoc est Amonoterpenoid octa-1,6-VII, et diene competit substituendi sibi yl III atpositions coetus et coetus hydroxy 3. Non fuit in loco isolatedfrom sicut plantae Ocimum canum.

Praeparatio

In 1950s, nearlyall linalool in unguentariam est essentialis olea solitaria a, particularlyfrom rosewood oleum. Currently, hic iam modum lascivio a munus commercial.
Cum linalool est momenti medium in in fabricare de Vitaminum E pluribus magnam veniam processus developed eius erat incipiens production.Preferred materiae et / vel intermedii sunt pinenes and6 yl-II-V-hepten- unum. Most gradu linalool pigmentaria, synthetica est.
I) absque essentialis olea: Linalool potest inveniri separatim ab fractionaldistillation essentialis olea, exempli gratia, rosewood et oleum coriandri coloris oleum, oleum rosewood Brasiliensium cuius est maxime momenti.
II) synthesis de Î ± -pinene: Î ± terebinthinae oleum de -Pinene est selectivelyhydrogenated pinane-cis, quae oxidized per oxygeni coram radicitus ex substantia initiator LXXV% ad mixtisque de pinane Cis-et XXV% transpinane Arabidopsis mixtisque; apud vel reducitur ad correspondingpinanols bisulfite in sodium (NaHSO3), vel cum catalyst. Thepinanols potest separari per destillationem sunt numeri fracti sunt pyrolyzed tolinalool ac (?) - Î ± - cedit pinene pinanol Cis, et (+) - linalool, cum (?) - linalool ex adeptus est trans-pinanol.
III) synthesis a ?? - pinene: quia route demonstrationis meae constructionem quaerere, videatur underGeraniol. Insuper et hydrogenii ad myrcene chloride (adeptus eos dictos, ex pinene) results in mixtisque geranyl, neryl et linalyl chlorides. Mixtisque of this reactionem cum acetic acida acetate coram aeris sodium (IV) LXXX% tradite 75a in chloride dat linalyl acetate. Linalool aftersaponification adeptus est.
IV) synthesis de V-VI-yl hepten-unus-II, VI, cum in summa exstant linaloolstarts yl-II-V-hepten unum; Hoc enim summatim veniam processus beendeveloped magnis composita
a. Ut etiam ex acetylene acetone formation of praecessi in II-III-yl butyn-of-II, quae sunt hydrogenated yl II-II-III-of-buten in conspectu eius conversa est productum ex substantia Palladii catalyst.This acetoacetatederivative cum diketene aut cum aethylicus. In permutandis acetoacetateundergoes quando tale incalescit coëunt (Carroll reactionem) hepten-II-V ad VI-unus-yl:
b. In alio processus, yl V-VI-unus-II-hepten adeptus est per reactionem of2 yl-III-II-of-buten isopropenyl yl sive secuta est per Claisenrearrangement:
c. A tertia compositio fromisoprene incipit, quod convertitur in II-III-yl butenyl chloride per addition of hydrogenii chloride. De catalytic reactionem est chloridewith acetone coram amount of organicum et basis leadsto V-VI-yl hepten-II, qui,
d. In alio processus, yl V-VI-hepten-II-VI-unus sit adeptus a isomerizationof yl-II-VI-hepten one.The habetur etiam paratus est in duo gradus fromisobutylene et formaldehyde. Methyl-III-III-l-of-buten nascitur in firststep, convertitur in yl VI-II-VI-unus-hepten per reactionem, et acetone.6 Methyl-V-II-hepten in carne conversum est, ut exhibeatis bybase acetylene, cum egregia linalool Catalyzed ethynylation dehydrolinalool. Haec de triplici ea ratione vinciatur hydrogenation isfollowed per electionem selectivam ad attrahunt coram duplex vinculum ipsum Palladii de catalyst.

Aroma limine values

Staphylococcus aureus, in IV 10ppb

Saporem limine values

Tastecharacteristics ad V ppm, viridis, pomum et pirum et oleosum ac cerae, slightlycitrus nota.

Contact allergens

Linalool aterpene dux est constituens ipsam linaloe oleum etiam in olea Ceyloncinnamon, saxifragium, aurantiaco flore: bergamot, Artemisia balchanorum, Ylang, Ylang. Et hoc ipsum est saepe solebat illa odorata, per sensitizer theway ex prima et secundarium oxida tion products. Sicut odor allergen, linalool ut habeat medicamentis intra EU in omni vulgi multitudine:

Research anticancer

Pisces et solida facta antitumoractivities studiis S-tumore bearingSwiss albinomice CLXXX. Relinquitur oxidative accentus per inductionem, cum anantitumoractivities exitum. Prae cyclophosphamide, antioxidanteffects wereobserved in iecoris ac crebritate modulorum suaviorem in proliferation de tumore, bearingmice spleencells per provocantibusque ad lipopolysaccharides, cum gravissime affectus bothwere bycyclophosphamide (Costa et al. MMXV).

Synthesis eget

Potest esse a preparedsynthetically myrcene et incipiens a dehydrolinalool; per rectificationes, a subsequent beobtained possit, et, fractis distilla theoils de Cajenne rosewood (Licasia guaianensis, Ocotea caudata), Brazilrosewood (Ocotea parviflora), Mexicanus linaloe, Shiu (Cinnamomum camphoraSieb. f. linalooifera) et semina coriandri album (Coriandrum sativum L.) .

et rudis materiae

Kalium hydroxide -> Calcii carbonas -> oleum Terebinthino -> alpha-PINENE -> Magnesium cadmiae -> eucalyptus oleum Citriodara -> SODIUM ACETYLIDE -> Myrcene -> Methyl-V-VI-II-hepten unum -> CORIANDRUS oLEO -> Dehydrolinalool -> oleum ho -> Bois de rosa tinguere,

Praeparatio Products

Citral -> Eugenol -> Geraniol -> NEROL -> Linalyl acetate -> Isophytol -> rosa -> Myrcene -> Tetrahydrolinalool -> LINALYL propio -> LINALYL BUTYRATE -> LINALYL ISOBUTYRATE