Diethyl Malonate

Product nomen:

Diethyl malonate

Synonyma:

MALONICA ACIDUM DIETHYL ESTER; MALONICE ESTER, ETHYL MALONATE, Ethyl propanedioate, FEMA MMCCCLXXV; DEM, DICARBETHOXYMETHANE, DIETHYL MALONATE

CAS;

105-53-3

MF:

C7H12O4

MW:

160.17

EINECS:

203-305-9

Categoria:

Aedificationem cuneos, C6 ad C7; Carbonyl Compounds, Donec Synthesis, Esters, Organica; Organic aedificium cuneos

Mol fasciculi:

105-53-3.mol

punctum liquescens 

-50 °C

fervens 

199 °C(lit.)

density 

1.055 g/mL ad 25 °C(lit.)

vapor density 

5.52 (vs. caeli);

vapor pressura 

1 mm Hg (40 °C)

FEMA 

2375 | DIETHYL MALONATE

refractivus index 

n20/D 1.413(lit.)

Fp 

212 °F

repono temp. 

Repone infra +30°C.

solubility 

20.8g/l (Externi MSDS)

pka

13.5(at 25℃)

forma 

Liquid

explosive modum

0.8-12.8%(V)

Aqua Solubility 

Miscuntur cum alcohol ethylo, aethere, chloroformi et benzene. Leviter aqua misceri potest.

JECFA Number

614

Merck 

14,3823

BRN 

774687

Stabilitas:

Stabulum. Combustible. Agentibus oxidizing fortis repugnat;

InChIKey

IYXGSMUGOJNHAZ-UHFFFAOYSA-N

CAS Reference

105-53-3;

NIST Chemia Reference

Acidum propanedioicum, diethyl niensis (105-53-3)

EPA Substantia Registry System

Diethyl malonatus (105-53-3)

Periculum Codes 

Xi

Periculum Denunciationes 

36/37/38-36

Salus Denunciationes 

24/25-26

WGK Germania 

1

RTECS 

OO070000

Autoignition Temperature

435 °F

Aleam Nota 

Irritant

TSCA 

Ita

HS Code 

29171910

Toxicity

LD50 viva voce in Rabbit: 15720 mg/kg LD50 dermal cuniculus > 16000 mg/kg

Chemical Properties

hyalina liquida

Chemical Properties

Diethyl malonatum habet odorem languidum, amoenum, aromaticum.

usus

barbiturates fabricare.

Praeparatio

Acidum chloroaceticum regentem ad acidum cyanoaceticum utentem sodium cyanidum et saponificationem subsequentem; acidum malonicum tandem esterificatum per azeotropicum distillationis cum ethanolo in benzene

Gustus limina values

Gustus characteres in 50 ppm: dulcis et fructuosus cum pomo et pineapple nuances.

salus Profile

Leniter toxicus per ingestionem. Pellis irritamentum. Liquor combustibilis, quando exponitur calori vel flammae; potest agere cum oxidizing materiae. Ad ignem pugnare, aqua ad stratum ignem, spumam, CO2, arida chemica. Cum calefacta compositione emittit fumum acrem et fumos exagitans. Vide etiam ESTERS.

Purificationis Methodi

Si nimium impurus (IR, NMR) niensis (250g) in balneo vapore calefactus pro 36 horis absolutis EtOH (125mL) et conc H2SO4 (75mL), postea sub pressionibus fractis destillandis. Alioqui sub pressione reducta fracte destillant et mediam fractionem ferventem constantem colligant. [Beilstein 2 IV 1881.]

Praeparatio Products

2-HEXYLDECANOIC ACID-->CYCLOPENTYLACETICUM ACID-->5-CHLORO-BENZOFURAN-II-CARBOXYLICUM ACIDUM ETHYL ESTER-->ENOXACIN-->PHENYLBUTAZONE-->4,6-DIchloro-2-(methylsulfonyl) pyrimidine-->2-BARBOXYLIC. ESTER-->5-NITROBENZOFURAN-2-CARBOXYLIC ACIDUM-->4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE-->Diethyl chloromalonatum->ETHYL. 7-METHOXYBENZOFURAN-2-CARBOXYLATUM-->5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE-->2-Mercapto-4,6-dimethoxypyrimidine-->4-Chloro-6-methoxy-2-(methylthio) pyrimidine ,98%-->5-7-BIS(TRIFLUOROMETHYLIUM)-4-HYDROXYQUINOLINE-->2-(TRIFLUOROMETHYLIUM) -4-HYDROXYPYRIMIDINE-5-CARBOYLICUM ACIDUM->5-NITROPYRIDINE-II-CAIDUM CARBOXYLUM. ESTER-->2,4-Dihydroxypyrimidium-5-carboxylicum-->4,6-dihydroxy-2-methylpyrimidium-->5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLICUM ACIDUM-->4-CHLORO-VII-(trifluoromethyl)quinolinum 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATUM-->4-HYDROXY-V,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLICUM ACIDUM ETHYL ESTER-> TRIETHYLUM 1,1,2-ETHANETRICARBOXYLATUM-> ETHYL 2-(ETHYLTHIO) -4-HYDROXYPYRIMIDINE-5-CARBOXYLATUM-->2,4,5-Trifluorophenylaceticum acidum-->Gliclazide-->2-MERCAPTOPYRIMIDINE-4,6-DIOL-->ETHYLUM 4-HYDROXYL-YL-6-(TRIFLUOROMETHYL-YL-YL->YL--. butylmalonate-->2-AMINODIETHYLMALONATE-->2-amino-6-chloropyrimidin-4(3H)-one->3- CARBETHOXYUMBELIFERONE-->DIETHYL. 2-(2-CYANOETHYL) MALONATE-->5-CARBETHOXYURACIL-->3-CARBETHOXY-2-PIPERIDONE-->2-Amino-6-hydroxypyrimidin-4(3H)-unum ,97%-> Sulfamonomethoxinum

Rudis materiae

Etanol--> Acidum hydrochloricum --> Acidum sulphuricum --> Sodium carbonas --> Natrium cyanidum --> Acidum Malonicum --> Acidum chloroaceticum --> Acidum chloroaceticum salis Natrium --> Acidum cyanoaceticum --> Disodium hydrogenorthophosphate --> MALONICUM ACIDUM DISODIUM SAL