Acidi cinnamic

Product nomen:

Acidum cinnamic

Synonyma:

alta munditia cinnamic acid kf-wang(at)kf-chem.com;CitricAcidGr(Monohydrate);CinnamonAcid;Benzenepropenoic ACIDUM;3-Phenylpropenoic; CINNAMIC-ACIDUM, TRANS-(SH); ZIMTSAEURE ERG.B.6; Phenylacrylic acidum

CAS;

621-82-9

MF:

C9H8O2

MW:

148.16

EINECS:

210-708-3

Categoria:

Mol fasciculi:

621-82-9.mol

punctum liquescens 

133 °C(lit.)

fervens 

300 °C(lit.)

density 

1.2475

FEMA 

2288 | CINNAMIC-ACIDUM

refractivus index 

1.5049 (aestima)

Fp 

>230 °F

pka

pK (25°) 4.46

Aqua Solubility 

511.2mg/L(25 C)

JECFA Number

657

Stabilitas:

Stabulum. Combustible. Agentibus oxidizing fortis repugnat.

CAS Reference

621-82-9 (CAS Reference)

NIST Chemia Reference

Acidum 2-propenoicum, 3-phenyl-(621-82-9)

EPA Substantia Registry System

cinnamic Acidum (621-82-9)

Periculum Codes 

Xi

Periculum Denunciationes 

36/37/38

Salus Denunciationes 

26-36

WGK Germania 

1

RTECS 

GD7850000

Toxicity

LD50 (g/kg): 3.57 viva voce in mures; > 5.0 lepores in derlly (Letizia)

Contenta Analysis

D recte ponderare Formulae specimen quod antea exaruit pro III horis in sicciore repleti cum silica gel; adde 0.1mol/L hydrogenii.

Toxicity

GRAS (FEMA). 
LD50 2500 mg/kg (rat, oralis)

Limited usu

FEMA (mg/kg): Mollis bibit 31; 40 Frigidus potus; confectionary 30; Pistrinum 36; Gum 10 . 
Accipe modum ut modum (FDA§172.515, 2000).

Chemical Properties

Videtur quod album prismata monoclinica cum odore tenui cinnamomi. Solutum est in ethanol. methanolum, aethereum petroleum et chloroforme; in benzene facile solutum; aether, acetum, aceticum, aceticum, carbo carbonis dissolvere et olea, sed insolubile aquam.

usus

1. potest esse quod rudis materias fabricandis niensis aromatibus et veneficiis. 
2. Potest adhiberi ad reagentia chemica tum utendum est unguentum syntheticum et pharmaceuticum. 
3. GB 2760-96 eam praebet ad sapores licitos edendos. Hoc est maxime usus est confectio aromatum et cerasorum, apricotorum, mellis saporis. Potest etiam adhibenda est anti- corrosio tutelae novorum pomorum et leguminum.

Productio methodo

1. potest esse nactus per co-calefactio reactionem inter benzyl chloride et sodium acetatis. 
2. Generari etiam potest per reactionem cocalefactionem inter benzaldehyde et sodium acetate (vel potassium acetate) coram a * dehydrogenating agente. 
3. Praeparari etiam potest per: miscens benzoylaceton, sodium carbonas et candida, acidum sodium cinnamicum generantes, sequitur processus cum sulfate.

Chemical Properties

monoclinic crystallis

Chemical Properties

Acidum cinnamic is cum ardore sapore paene inodoro, dein dulcedo et simile persicum.

Praeparatio

Duo isomers, trans- et Cis- dentur; the trans-isomer is of interest for use in CONDITIO; in praeter extractionem e fontibus naturalibus (storax) praeparari potest sic: (1) de benzaldehyde, sodium anhydroum acetatis et aceticis anhydride in praesentia pyridine (Perkin reaction); (2) from * benzaldehyde and ethyl acetate (Claisen condensatio); (3) from benzaldehyde et acetylene chloride; (4) ex oxidatione benzylidene acetone cum sodium hypochlorite.

salus Profile

Venenum by intravenous and intraperitoneal routes. Mediocriter toxicus per ingestionem. Pellis irritamentum. Liquoris combustibilis. Cum calefacta in compositione emittit acria fumus, fumus.

Synthesis chemica

Rainer Ludwig Claisen (1851-1930), chemicus Germanicus, anno 1890 primum descriptus synthesis cinnamatum per aldehydes cum esters aromatico reagit. The reactio nota est sicut condensatio Claisen.

Purificationis Methodi

Crystallize in acido a*benzene, CCl4, aqua calida, aqu/EtOH (3, 1), vel 20% aqueus EtOH. Excoquatur eam at 60o in vacuo. Vapor volatile est. [Beilstein 9 IV 2002.]

Rudis materiae

Benzyl chloride --> Natrium acetatum trihydratum --> Potassium acetatis --> Calcium hypochlorite --> Acidum trans-cinnamicum --> Benzalaceton

Praeparatio Products

L-Phenylalanine-->2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol-->L-PHENYLALANINE